Carlton has made three changes for Saturday's clash with the Giants at Spotless Stadium.

The Blues will be without skipper Marc Murphy who looks set to undergo surgery after dislocating his shoulder.

Kristian Jaksch (ankle) and Andrew Carrazzo (toe) have also been ruled out injured.

Into the side come Cameron Wood, Chris Yarran and Brad Walsh.

Walsh will play his third AFL game after being upgraded from the rookie list ahead of Round 16, while the match will mark AFL game number 50 for Sam Rowe and Tom Bell.

Clem Smith, Tom Fields and Nick Holman have been named as the emergencies.

The match kicks off at Spotless Stadium at 1.45pm AEST on Saturday.

Carlton's team to take on GWS:

Backs17. Sam Rowe40. Michael Jamison15. Sam Docherty
Half-backs7. Dylan Buckley42. Zach Tuohy6. Kade Simpson
Centreline22. Jason Tutt35. Ed Curnow12. Blaine Boekhorst
Half-forwards2. Troy Menzel28. Tom Bell13. Chris Yarran
Forwards1. Andrew Walker10. Matthew Watson33. Andrejs Everitt
Followers8. Matthew Kreuzer9. Patrick Cripps24. Mark Whiley
Interchange36. Cameron Wood31. Matthew Dick46. David Ellard
 34. Brad Walsh  
Emergencies25. Clem Smith37. Tom Fields20. Nick Holman

In: Yarran, Walsh, Wood

Out: Murphy (shoulder), Carrazzo (toe), Jaksch (ankle)

Click here to see the Giants' team.