Carlton has been forced into making three changes for Sunday's blockbuster against Richmond at the MCG.

Youngsters Tom Williamson (back), Zac Fisher (achilles) and David Cuningham (adductor) have been ruled out with injury, replaced by Billie Smedts, Nick Graham and Jarrod Pickett.

The incoming trio impressed for the Northern Blues against Werribee at the weekend, with Pickett leading the charge.

The 20-year-old recorded 17 disposals, five tackles and two goals in a performance which earned high praise from Northern Blues coach Josh Fraser.

"I think it was his best game for the Club, certainly at VFL level," Fraser said.

"He was really exciting when he was near it, played game time on the wing which was great for him and he covered the ground as good as he has. He kicked two crucial goals as well."

The Blues will be aiming to tame the Tigers for the first time since the 2013 elimination final on Sunday.

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Carlton's Round 14 team:

Backs15. Sam Docherty14. Liam Jones23. Jacob Weitering
Half-backs20. Lachie Plowman22. Caleb Marchbank39. Dale Thomas
Centreline6. Kade Simpson9. Patrick Cripps46. Matthew Wright
Half-forwards35. Ed Curnow41. Levi Casboult12. Blaine Boekhorst
Forwards13. Jed Lamb30. Charlie Curnow1. Jack Silvagni
Followers8. Matthew Kreuzer4. Bryce Gibbs3. Marc Murphy (C)
Interchange33. Jarrod Pickett16. Billie Smedts32. Nick Graham
 5. Samo Petrevski-Seton  
Emergencies43. Simon White19. Liam Sumner11. Sam Kerridge 

In: Smedts, Graham, Pickett

Out: Cuningham (adductor), Williamson (back), Fisher (achilles)