The Carlton Football Club can confirm forward Jesse Motlop has ruptured his anterior cruciate ligament.
The injury occurred during training on Monday, with subsequent scans confirming the rupture.
Motlop will undergo surgery before commencing his rehabilitation towards a full recovery.
“Jesse has put in plenty of hard work in the pre-season, so we are really feeling for him at this time,” Carlton General Manager of Football Chris Davies said.
“While there is understandable disappointment right now, Jesse is the ultimate professional, who possesses great resilience, which will help as he moves through the recovery process.
“The Club and medical staff will continue to support Jesse during his rehabilitation.”